Excess cholesterol in macrophages within ocular blood vessels may help trigger neovascular, or “wet,” age-related macular degeneration (AMD), a laboratory study suggested.
A series of experiments in mice showed that cholesterol levels in macrophages from older mice were higher than in younger animals, apparently because of impairments in the ABCA1 cholesterol efflux mechanism, according to Rajendra Apte, MD, PhD, of Washington University in St. Louis, and colleagues.
Source: MedPage Today – Apr 3, 2013
